November 2025 Monthly Literature Search – Long Covid
This month’s literature search explores the multi-system illness Long Covid, bringing you recent articles on its prevalence, impact, pathogenesis, diagnosis, and treatment.
Grey literature
- Long COVID in Australia – a review of the literature, Summary - Australian Institute of Health and Welfare
- Long Covid Conference 2024, Victorian Agency for Health Information Long-COVID-Conference-Communique.pdf.aspx
- COVID-19: Clinical presentation and diagnosis of adults with persistent symptoms following acute illness ("long COVID") - UpToDate
- Post acute sequelae of COVID-19 (long COVID): Living evidence | Agency for Clinical Innovation
- Emerge Australia recommendations for Long Covid Management and Support
- Hidden Disability Sunflower A symbol for non-visible disabilities, also known as hidden disabilities or invisible disabilities. https://hdsunflower.com/au/
Full-text articles
Al-Aly, Z., & Topol, E. (2024). Solving the puzzle of Long Covid. Science, 383(6685), 830–832.
Alkodaymi, M. S., Omrani, O. A., Ashraf, N., Shaar, B. A., Almamlouk, R., Riaz, M., Obeidat, M., Obeidat, Y., Gerberi, D., Taha, R. M., Kashour, Z., Kashour, T., Berbari, E. F., Alkattan, K., & Tleyjeh, I. M. (2022). Prevalence of post-acute COVID-19 syndrome symptoms at different follow-up periods: a systematic review and meta-analysis. Clinical Microbiology and Infection, 28(5), 657–666.
Allard, N., Miller, A., Morgan, M., & Chakraborty, S. (2022). Post–COVID-19 syndrome/condition or long COVID: Persistent illness after acute SARS CoV-2 infection. Australian Journal of General Practice, 51(12), 952–957.
Astin, R., Banerjee, A., Baker, M. R., Dani, M., Ford, E., Hull, J. H., Lim, P. B., McNarry, M., Morten, K., O’Sullivan, O., Pretorius, E., Raman, B., Soteropoulos, D. S., Taquet, M., & Hall, C. N. (2023). Long COVID: mechanisms, risk factors and recovery. Experimental Physiology, 108(1), 12–27.
Barfar, E., Raei, B., Daneshi, S., Bagher Barahouei, F., & Hushmandi, K. (2025). The burden of COVID-19 based on disability-adjusted life years: a systematic review of available evidence. Frontiers in Public Health, 13.
Byambasuren, O., Stehlik, P., Clark, J., Alcorn, K., & Glasziou, P. (2023). Effect of covid-19 vaccination on long covid: systematic review. BMJ Medicine, 2(1), e000385.
Cárdenas-Rodríguez, N., Ignacio-Mejía, I., Mejía-Barradas, C. M., Ortega-Cuellar, D., Muñoz-González, F., Vargas-Hernández, M. A., Albores-Méndez, E. M., Ibáñez-Cervantes, G., Medina-Santillán, R., Hernández-Ortiz, A., Herrera-López, E., & Bandala, C. (2025). Post-COVID Condition and Neuroinflammation: Possible Management with Antioxidants. Antioxidants, 14(7), 840.
Castanares-Zapatero, D., Chalon, P., Kohn, L., Dauvrin, M., Detollenaere, J., Maertens de Noordhout, C., Primus-de Jong, C., Cleemput, I., & van den Heede, K. (2022). Pathophysiology and mechanism of long COVID: a comprehensive review. Annals of Medicine, 54(1), 1473–1487.
Chai, Y., Lam, I. C. H., Man, K. K. C., Hayes, J. F., Wan, E. Y. F., Li, X., Chui, C. S. L., Lau, W. C. Y., Lin, X., Yin, C., Fan, M., Chan, E. W., Wong, I. C. K., & Luo, H. (2025). Psychiatric and neuropsychiatric sequelae of COVID-19 within 2 years: a multinational cohort study. BMC Medicine, 23(1), 144.
Cutler, D. M. (2022). The Costs of Long COVID. JAMA Health Forum, 3(5), e221809.
Evcik, D. (2023). Musculoskeletal involvement: COVID-19 and post COVID 19. Turkish Journal of Physical Medicine and Rehabilitation, 1(1), 1–7.
Golzardi, M., Hromić-Jahjefendić, A., Šutković, J., Aydin, O., Ünal-Aydın, P., Bećirević, T., Redwan, E. M., Rubio-Casillas, A., & Uversky, V. N. (2024). The Aftermath of COVID-19: Exploring the Long-Term Effects on Organ Systems. Biomedicines, 12(4), 913.
Greenhalgh, T., Sivan, M., Perlowski, A., & Nikolich, J. Ž. (2024). Long COVID: a clinical update. The Lancet, 404(10453), 707–724.
Guntinas-Lichius, O., Bitter, T., Takes, R., Lee, V. H. F., Saba, N. F., Mäkitie, A. A., Kowalski, L. P., Nixon, I. J., & Ferlito, A. (2025). Post COVID-19 and Long COVID Symptoms in Otorhinolaryngology—A Narrative Review. Journal of Clinical Medicine, 14(2), 506.
Gusev, E., & Sarapultsev, A. (2024). Exploring the Pathophysiology of Long COVID: The Central Role of Low-Grade Inflammation and Multisystem Involvement. International Journal of Molecular Sciences, 25(12), 6389.
Holmes, A., Emerson, L., Irving, L. B., Tippett, E., Pullin, J. M., Young, J., Watters, D. A., & Hamilton, A. (2024). Persistent symptoms after COVID ‐19: an Australian stratified random health survey on long COVID. Medical Journal of Australia, 221(S9).
Kim, C., Lin, C., Wong, M., al Hamour Al Jarad, S., Gao, A., Kaufman, N., McDuff, K., Brown, D. A., Cobbing, S., Minor, A., Chan Carusone, S., & O’Brien, K. K. (2024). Experiences of physiotherapists working with adults living with Long COVID in Canada: a qualitative study. BMJ Open, 14(11), e086357.
Lok, L. S. C., Sarkar, S., Lam, C. C. I., Law, C. F., Chau, S. T., Leung, C. Y. T., Cheang, W. H., Li, T., Monteiro, O., & Baptista‐Hon, D. T. (2024). Long COVID across SARS‐CoV‐2 variants: Clinical features, pathogenesis, and future directions. MedComm – Future Medicine, 3(4).
Luetkemeyer, A. F., Chew, K. W., Lacey, S., Hughes, M. D., Harrison, L. J., Daar, E. S., Eron, J., Fletcher, C. v, Greninger, A. L., Hessinger, D., Li, J. Z., Mailhot, D., Wohl, D., Chayakulkeeree, M., Mendoza, J. L. A., Elistratova, P., Makinde, O., Morgan, G., Portsmouth, S., … Currier, J. S. (2025). Ensitrelvir for the Treatment of Nonhospitalized Adults with COVID-19: Results from the SCORPIO-HR, Phase 3, Randomized, Double-blind, Placebo-Controlled Trial. Clinical Infectious Diseases, 80(6), 1235–1244.
Michelen, M., Manoharan, L., Elkheir, N., Cheng, V., Dagens, A., Hastie, C., O’Hara, M., Suett, J., Dahmash, D., Bugaeva, P., Rigby, I., Munblit, D., Harriss, E., Burls, A., Foote, C., Scott, J., Carson, G., Olliaro, P., Sigfrid, L., & Stavropoulou, C. (2021). Characterising long COVID: a living systematic review. BMJ Global Health, 6(9), e005427.
Notarte, K. I., Catahay, J. A., Velasco, J. V., Pastrana, A., Ver, A. T., Pangilinan, F. C., Peligro, P. J., Casimiro, M., Guerrero, J. J., Gellaco, Ma. M. L., Lippi, G., Henry, B. M., & Fernández-de-las-Peñas, C. (2022). Impact of COVID-19 vaccination on the risk of developing long-COVID and on existing long-COVID symptoms: A systematic review. EClinicalMedicine, 53, 101624.
O’Mahoney, L. L., Routen, A., Gillies, C., Ekezie, W., Welford, A., Zhang, A., Karamchandani, U., Simms-Williams, N., Cassambai, S., Ardavani, A., Wilkinson, T. J., Hawthorne, G., Curtis, F., Kingsnorth, A. P., Almaqhawi, A., Ward, T., Ayoubkhani, D., Banerjee, A., Calvert, M., … Khunti, K. (2023). The prevalence and long-term health effects of Long Covid among hospitalised and non-hospitalised populations: a systematic review and meta-analysis. EClinicalMedicine, 55, 101762.
Ranque, B., & Cogan, E. (2025). Internal medicine at the crossroads of long COVID diagnosis and management. Frontiers in Medicine, 12.
Resendez, S., Brown, S. H., Ruiz Ayala, H. S., Rangan, P., Nebeker, J., Montella, D., & Elkin, P. L. (2024). Defining the Subtypes of Long COVID and Risk Factors for Prolonged Disease: Population-Based Case-Crossover Study. JMIR Public Health and Surveillance, 10, e49841.
Sugiyama, A., Takafuta, T., Sato, T., Kitahara, Y., Yoshinaga, Y., Abe, K., Chanroth, C., Ataa, A. G., Phyo, Z., Kurisu, A., Ko, K., Akita, T., Kishita, E., Kuwabara, M., & Tanaka, J. (2024). Natural course of post-COVID symptoms in adults and children. Scientific Reports, 14(1), 3884.
Thomas, J., Prgomet, M., Weeding, S., McGuire, P., Goodger, B., Joss, N., Mackintosh, C. F., McLeod, A., & Georgiou, A. (2024). A qualitative study of the general practice experience of diagnosing and managing long COVID: Challenges and practical recommendations. Australian Journal of General Practice, 53(10), 732–736.
Tsampasian, V., Bäck, M., Bernardi, M., Cavarretta, E., Dębski, M., Gati, S., Hansen, D., Kränkel, N., Koskinas, K. C., Niebauer, J., Spadafora, L., Frias Vargas, M., Biondi-Zoccai, G., & Vassiliou, V. S. (2025). Cardiovascular disease as part of Long COVID: a systematic review. European Journal of Preventive Cardiology, 32(6), 485–498.
Tsampasian, V., Elghazaly, H., Chattopadhyay, R., Debski, M., Naing, T. K. P., Garg, P., Clark, A., Ntatsaki, E., & Vassiliou, V. S. (2023). Risk Factors Associated With Post−COVID-19 Condition. JAMA Internal Medicine, 183(6), 566.
Vlaming‐van Eijk, L. E., Tang, G., Bourgonje, A. R., den Dunnen, W. F. A., Hillebrands, J., & van Goor, H. (2025). Post‐COVID ‐19 condition: clinical phenotypes, pathophysiological mechanisms, pathology, and management strategies. The Journal of Pathology.
Yousaf, A. R., Mak, J., Gwynn, L., Lutrick, K., Bloodworth, R. F., Rai, R. P., Jeddy, Z., LeClair, L. B., Edwards, L. J., Olsho, L. E. W., Newes-Adeyi, G., Dalton, A. F., Caban-Martinez, A. J., Gaglani, M., Yoon, S. K., Hegmann, K. T., Phillips, A. L., Burgess, J. L., Ellingson, K. D., … Saydah, S. (2025). COVID-19 Vaccination and Odds of Post–COVID-19 Condition Symptoms in Children Aged 5 to 17 Years. JAMA Network Open, 8(2), e2459672.
Zeraatkar, D., Ling, M., Kirsh, S., Jassal, T., Pitre, T., Chakraborty, S., Turner, T., Turkstra, L., McIntyre, R. S., Izcovich, A., Mbuagbaw, L., Agoritsas, T., Flottorp, S. A., Garner, P., Couban, R. J., & Busse, J. W. (2025). Interventions for the management of post-COVID-19 condition (long COVID): protocol for a living systematic review and network meta-analysis. BMJ Open, 15(2), e086407.
Zhang, R., Gu, X., Zhang, H., Guo, Y., & Cao, B. (2025). Long COVID: current research and future directions. Infectious Diseases & Immunity.